The American Cleaning Institute (ACI)

Cleaning Product Ingredient Safety Initiative


The Cleaning Product Ingredient Safety Initiative (CPISI) is an online database designed to serve as a resource for accessing and understanding information related to the safety of ingredients used in household cleaning products.

CPISI illustrates how safety assessment data from publicly available sources can be incorporated into a risk assessment methodology for household cleaning product ingredients used by member companies in the formulation of household cleaning products sold in the United States. For each unique ingredient, chemical hazard data were identified through a number of public online sources and databases. Exposures were characterized for each ingredient based on the product types and their typical applications. These findings were then combined to produce a conservative human health screening level risk assessments with a transparent model and all methodology. Please note these assessments are presented for illustrative purposes only and should not replace a robust risk assessment.

CPISI provides the following:

  • A searchable inventory of ingredients in U.S. household cleaning products produced by members of ACI (as of the most recent product survey in 2016/2017)
  • Exposure information for each ingredient within each product category in which it is used
  • Hazard information for each ingredient 
  • No-effect values derived from regulatory benchmarks, published assessments, or available hazard data for oral, dermal, and inhalation exposure pathways (where these could be derived) applicable to potential systemic, reproductive, or developmental impacts from daily exposure

History of CPISI

ACI developed CPISI as one of its many efforts to shed light on the safe use of ingredients in our members’ products including the underlying scientific data and the methods in which these data are applied in making decisions. The first step in this initiative was to compile and make publicly available a comprehensive inventory of ingredients used by members in the formulation of home use consumer cleaning products sold in the United States. ACI released the Ingredient Inventory in 2012 with an update in 2016/2017. 

Hazard data for each cleaning product ingredient in the Inventory were identified to create a database that contains links to publicly accessible data. Chemical hazard data for each unique ingredient was found through a number of online sources and databases. While hazard data were being collected, exposure models were run to quantify human health exposure to each ingredient from products in which it occurs. 

Exposure estimates, hazard data, and past findings were combined to produce a human health screening level risk assessments for the 494 ingredients for which publicly available hazard data were available. A screening-level risk assessment is a highly conservative initial assessment of the chance that an ingredient in a cleaning product may pose a risk of effect during use. Each screening level risk assessment for a specific ingredient was based on the most defensible and authoritative data compiled, and was designed to err on the side of caution, making conservative assumptions wherever uncertainty or a range of circumstances might be expected. Because of this, findings of "no" or "low risk" are relatively certain, while findings that there is a potential for risk are uncertain, and will undergo further assessment.

Detailed Project Background

Using the Database

ACI makes no warranty, expressed or implied, as to the results obtained from the use of this data, and neither ACI nor its members shall have any liability for the accuracy or applicability of any information on this web site. While public data sources can be of value, it is necessary to assess products pursuant to all applicable scientific and regulatory standards. 


To search for an ingredient in a cleaning product, you may use the search box below, or click the link to see a list an alphabetical listing of all of the ingredients included in the Ingredient Inventory. The list can be searched by entering either the ingredient CAS number or name or partial name into the search box. Clicking on each ingredient name will lead to a new page that provides a summary of the hazard and exposure data collected, along with a summary of the screening-level risk assessment results.


There are many different naming conventions that can be used to refer to the same ingredient. To compile the Inventory, multiple names for the same ingredient were often consolidated; also, names that were general were related to more specific sets of ingredients. If the name of the ingredient you are looking for does not appear below, you can access the Ingredient Naming Translator. The Translator lists all of the possible naming conventions for an ingredient that were encountered in the survey of products and identifies the standardized names or names associated with it.

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